Composition for oral inflammatory diseases comprising hydrogen peroxide and chromium trioxide



May 21, 1968 A. F. ACCETTA 3,384,542

COMPOSITION FOR ORAL INFLAMMATORY DISEASES COMPRISING HYDROGEN PEROXIDE AND CHROMIUM TRIOXIDE Filed May 9. 1966 INVENTOR. An/hony FAcce/fa Alto/nay United States Patent COMPOSITION FOR ORAL INFLAMMATORY DISEASES COMPRISING HYDROGEN PER- OXIDE AND CHROMIUM TRIOXIDE Anthony F. Accetta, 375 Oakford St.,

West Hempstead, N.Y. 11552 Filed May 9, 1966, Ser. No. 548,562 2 Claims. (Cl. 167-60) ABSTRACT OF THE DISCLOSURE Oral inflammatory diseases, such as gingivitis and pyorrhea, are treated by the oral application of a mixture of 3-10 weight percent hydrogen peroxide in aqueous solution and chromic acid in an amount, per fluid ounce of hydrogen peroxide solution, of 0.00250.1 g. of chromic acid on the dry basis.

This invention relates to the treatment of oral inflammations. It is more particularly concerned with oral treatments of inflamed tissues and a method for dispensing them.

As is well known in the art, gum inflammations, such as gingivitis and its more manifest forms, e.g., pyorrhea, are characterized by the presence of anaerobic bacteria in the gum pockets. Various proposals have been made to combat such inflammations. In the main, such proposed treatments require professional administration and leave little room for intermediate private, personal continuation of treatment. This occurs because, in general, the treating material should be freshly prepared and such treatment is not generally available to the average patient, even on a supplementary basis, outside of professional treatment. As will be readily recognized, supplementary treatment, complementing professional treatment, is a highly desired objective.

In accordance with the present invention there have been discovered freshly-prepared mixtures for the treatment of inflamed tissues, particularly in the gums, and a convenient means for non-professional administration thereof.

Accordingly, it is a broad object of this invention to provide a means for treating inflamed tissues. Another object is to provide for treatment of inflamed gum areas. A specific object is to provide a dispensing device for treating inflamed tissue and means for supplying therefrom freshly prepared treating mixtures. Other objects and advantages of this invention will become apparent to those skilled in the art from the following detailed description considered in conjunction with the drawings, in which:

FIGURE 1 is a sectional view of an embodiment of the dispenser and dispensing means of this invention; and

FIG. 2 is a sectional view of another embodiment of the dispenser and dispensing means of this invention.

In general, this invention provides a mixture for treating inflamed tissue that consists essentially of freshly admixed aqueous hydrogen peroxide solution and chromium trioxide; said hydrogen peroxide solution containing between about 3 and about weight percent hydrogen peroxide and the amount of chromium trioxide being, per fluid ounce of hydrogen peroxide solution, between about 0.0025 g. and about 0.1 g. on the dry basis. It also provides a method for treating inflamed tissue that comprises applying the freshly prepared mixture to said tissue.

This invention further provides a dispensing unit for treating inflamed tissue that comprises a substantially main body portion, made of resilient material, which tapers and curves to a capped discharge opening, which main body portion contains a first oxygenating compo- 3,384,542 Patented May 21, 1968 nent; a puncturable waterproof barrier near the bottom end of said main body portion, which forms a compartment separate from said main body portion, which compartment contains a second oxygenating component; and an end seal for said compartment.

As indicated hereinbefore, the primary purpose of this invention is to provide treating mixture that can be used, when freshly prepared, in home gum treatment; and a feasible means for mixing and applying the treating mixture. In describing this invention use is made of the terms first oxygenating component to designate the materials to be admixed to form the oxygen-releasing treating mixture. It is not intended to imply that one is primary to the other. In many cases, both components can release oxygen when the two are combined. The first component in the main body portion is used in the greater amount, volume-wise.

The preferred treating mixture of this invention is a freshly prepared mixture of chromium trioxide and aqueous hydrogen peroxide solution. It has been proposed to use chromium trioxide solution for gum treatment, but due to its relatively high acidity, this material actually lattacks healthy tissue in the mouth and burns it. Surprisingly when chromium trioxide is admixed with hydrogen peroxide solution, the resultant mixture when admixed with saliva and blood in the mouth is nearly neutral. This mixture can be made completely neutral or alkaline (up to pH of 9) by adding to the hydrogen peroxide solution a few drops of a saturated aqueous solution of sodium perborate or borax (N21 B O -10H O). It is significant to note that either mixture will not adversely affect the delicate, normal healthy surrounding tissues covering the tongue, the cheeks, the floor of the mouth, the palate, or the throat. Thus, when admixed in proper proportions this mixture is safe and effective for home gum treatment.

The chromium trioxide can be added in the form of an aqueous solution or in the solid form, as a tablet or crystals. In general, per fluid ounce (30 cc.) of 3-10% aqueous hydrogen peroxide solution, there will be used 0.25 to 1 cc. of an aqueous solution containing 1-10 weight percent (preferably 6-8) chromium trioxide. On a dry weight basis the amount of chromium trioxide used will be between 0.0025 g. and 0.1 g. Preferably, per 30 cc. of 3% hydrogen peroxide solution there will be used 0.03- 0.04 g. chromium trioxide (dry weight basis) or 0.5 cc. of 6-8% solution. Preferably, but not necessarily, the hydrogen peroxide solution will contain a very small amount of a preservative, such as urea or acetanilid, and flavoring agent.

EXAMPLE To 30 cc. 3% aqueous hydrogen peroxide solution (containing not over A grain acetanilid per fluid ounce) in a vial were added 6 drops (0.5 cc.) of an 8 weight percent aqueous solution of chromium trioxide. Within a minute, the resulting mixture darkened and vigorous evolution of nascent oxygen was observed. After about 2 minutes, the mixture was applied to inflamed gum tissue. This mixture can be applied either in a light spray or a light stream (liquid).

There are other mixtures which, when freshly prepared will produce nascent oxygen. Examples of such mixtures of solutions of chromium trioxide and potassium permanganate; of hydrogen peroxide and sodium chloride; and of chromic trioxide and sodium perborate. The mixture of this invention, such as shown in the example, however, is outstandingly effective for treatment of inflamed tissues. More significantly, it is completely safe for use in home treatment. For best results the user should have the tartar removed periodically by the dentist, so that the mixture can reach the affected areas more readily. Between dental visits, the mixture of this invention will be applied by the user but no more than 2-3 times a week for a period of about six weeks. The above procedure of professional and home treatment should be repeated in about six months. Although mixing proportions have been based upon one-ounce (30 cc.) quantities, about /2 ounce is usually sufficient per home treatment.

When applied as aforedescribed, the mixture of this invention will relieve the inflammatory, swollen, and tender conditions found in the pericoronal areas around unerupted or partially erupted wisdom teeth. It will also relieve inflammatory, swollen, and tender areas which are the result of pressure and food accumulations found under fixed or stationary bridges or ill-fitting removable bridges or plates. Most importantly, after a few home treatments the gums and diseased tissues will begin to exhibit a more natural healthy color and bleeding will significantly decrease.

In an embodiment of this invention, as shown in FIG. 1, the dispensing unit comprises a substantially cylindrical main body and a curved and tapering discharge element 11 having a discharge or dispensing opening 12. In its assembled condition, the dispensing unit is sealed with a screw cap 13, aflixed to the unit by threads 14.

Near the lower end, or the end removed from the discharge element 11, the dispensing unit is provided with a waterproof barrier 15, thus forming a compartment 16 in the lower end of the unit. This compartment 16 is sealed by means of a sealing element 17. As shown in FIG. 1, the sealant 17 can be a compression-fitted resilient element or it can be affixed by a suitable adhesive that is adapted to re-sealing. The entire lower portion is protected by a screw cap 20.

In operation, the unit (FIG. 1) contains, in the main body portion 18, the first oxygenating component, such as hydrogen peroxide. In the other compartment 16 is a solid material or tablet 19 of the second oxygenating component, e.g. chromic oxide. The tablet 19 can be, if desired, encased in a protective plastic covering preferably coextensive with the waterproof carrier .15. To administer the oral treatment, with the discharge end pointed down, screw cap 20 is removed. Then, pressure is exerted upon the tablet .19 to force it through the element into the prime oxidizer in the main body portion 18 to admix therewith. The screw cap is replaced and the other cap 13 is removed. When the action of the oxidizer components has taken place, usually 1-2 minutes, the freshly mixed mixture is applied to the inflamed areas via the opening 12, by squeezing, i.e., compressing, the re- 4 silient main body 10 to force the active, freshly-prepared mixture out of the main body 18.

In FIG. 2, there is shown a similar, but dilferent, embodiment from that of FIG. 1. This embodiment is generally like that of FIG. 1, except for the compartment 16 and the sealant 17. Thus only the lower end is shown in FIG. 2. In this case, the compartment contains, instead of the tablet 19, a fluid, such as an aqueous solution of chromic trioxide. Also, as shown, the preferred form of sealant is a screw cap 20 affixed to the main body 10 by threads 21, but which is not fully seated. The cap 20 is provided with a piercer 22.

In the embodiment of FIG. 2, the operation is similar to that of FIG. 1. Thus, in an inverted position with discharge element 11 pointed downward, the cap 20 is completely seated, whereby the barrier 15 is pierced by the piercer 22 to permit admixture of the solution in compartment 16 with the first oxygenating component in compartment 18. Then cap 13 is removed. After the fresh admixture is prepared, it is administered to inflamed areas via the opening 12, by compression of the main body 10.

Although the present invention has been described with preferred embodiments, it is to be understood that modifications and variations may be resorted to, without departing from the spirit and scope of this invention, as those skilled in the art will readily understand. Such variations and modifications are considered to be within the purview and scope of the appended claims.

What is claimed is:

1. A mixture for treating inflamed tissue that'consists essentially of freshly admixed aqueous hydrogen peroxide solution and chromium trioxide; said hydrogen solution containing between about 3 and about 10 weight percent hydrogen peroxide and the amount of chromium trioxide being, per fluid ounce of hydrogen peroxide solution, between about 0.0025 g. and about 0.1 g. on the dry basis.

2. A method for treating imflamed tissue that comprises applying to said tissue a mixture described in claim 1.

References Cited UNITED STATES PATENTS 7/1926 Shoub 167-60 OTHER REFERENCES RICHARD L. HUFF, Primary Examiner. 

